ATM, ATR, Chk1
G2/M の部分の「肩」がなくなりますか?
ノー。実験系は以下など。
Cliby WA, Roberts CJ, Cimprich KA, Stringer CM, Lamb JR, Schreiber SL, Friend SH.
Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpoints.
EMBO J. 1998 Jan 2;17(1):159-69. |
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